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Table of Antipsychotics

Drug	Receptor Affinity					Main Side Effects
	D₁	D₂	mACH	5HT₂		EPS	Sed.	Hypo.	Other
Typical
Chlorpromazine	++	+++	++	++		++	++	++	Increased prolactin (gynaecomastia) Hypothermia Anticholinergic effects Hypersensitivity reactions Obstructive jaundice
Thioridazine	+	++	++	++		+	++	++	As chlorpromazine, but does not cause jaundice
Haloperidol	+	+++	+ / -	+		+++		++	As chlorpromazine, but does not cause jaundice Fewer anticholinergic side effects
Flupenthixol	++	+++	-	+++		++	+	+	Increased prolactin (gynaechomastia) Restlessness

Atypical
Sulpiride		+++				+	+		Increased prolactin (gynaecomastia)
Clozapine	++	++	++	+++			++	+	Risk of agranulocytosis Seizures Sedation Salivation Anticholinergic side effects Weight gain
Risperidone		++	++	+++		+	++	+	Weight gain EPS at high doses Hypotension
Sertindole		++		+++		+	+	++	Ventricular arrhythmias Weight gain Nasal congestion
Quetiapine		+	+	+		+	++	++	Tachycardia Agitation Dry mouth Weight gain

Table reproduced from: Rang, H. P., Dale, M. M., Ritter, J. M., & Moore, P. K. (2003). Pharmacology (5th Edition ed.). London: Churchill Livingstone, Elsevier Limited.

Table Legend

D₁ = Dopamine Receptor 1

D₂ = Dopamine Receptor 2

mACH = Muscarinic Acetylcholine

5-HT₂ = Serotonin Receptor 2

EPS = Extra-pyramidal Side Effects

Sed. = Sedation

Hypo. = Hypotension

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